Progesterone’s role in frozen embryo transfers

Painful daily injections? Messy creams, gels, or inserts? Progesterone plays a vital role in pregnancy and frozen embryo transfers (FET), but there must be an easier way to administer it. We need your help to find out.

Carolina Conceptions is currently recruiting patients for a clinical trial sponsored by IBSA Group that is researching easier methods to administer the hormone progesterone.

Researchers want to find out if injecting progesterone by subcutaneous injection, an injection under the skin, is as effective as the current methods, which include injections into a muscle or vaginal gels, creams, or inserts. These methods can be painful, messy, and stressful.

Eligible subjects will have their frozen embryo transfer cycle covered.

Who is eligible to help us make progress?

  • Women ages 35-42.
  • Have regular menstrual cycles (24-38 days).
  • Are planning a single embryo transfer.
  • Have completed a normal uterine cavity evaluation, such as hysteroscopy, hysterosalpingogram, or SIS, within the past year.
  • Have a normal pap smear.

 Eligible participants who join the study will:

  • Attend scheduled clinic visits.
  • Have blood drawn to evaluate hormone levels.
  • Complete transvaginal ultrasounds designed to monitor changes to the ovaries, uterine lining or pregnancy, if applicable.
  • Receive study medications to self-administer as instructed by the clinic staff.

For a complete list of eligibility criteria, visit NCT04549116 or visit for more information.

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