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Controlled ovarian hyperstimulation (COH) includes the treatment options of ovulation induction and superovulation.  COH protocols can be used in combination with either timed intercourse (TIC) or intrauterine insemination (IUI).


Ovulation Induction

When a woman has irregular periods or no periods at all, it indicates that she is not ovulating in a regular, reliable manner.  Lack of ovulation means that an egg is not released for that month as it should, which is one of the leading causes of infertility.  Various disorders can cause ovulatory dysfunction, including polycystic ovary syndrome and disorders of the pituitary gland such as hyperprolactinemia, hypothyroidism, and functional hypothalamic amenorrhea.

Ovulation disorders can be treated with ovulation induction, which involves taking medications to stimulate a single egg to grow and release at the right time of the month.



When a woman has regular monthly periods, this is a good indication that she has normal ovulation and is releasing a single egg each month.  For couples with unexplained infertility, or for women of advancing age, we may recommend superovulation as the treatment of choice.  Superovulation is a method in which our goal is to allow for multiple mature eggs to release per month in order to increase your chance of pregnancy.  As more eggs release, the risk for multiples (twins, etc.) increase.  Your physician can discuss these risks with you based on your individualized treatment plan.


COH Medications

Your doctor will determine your plan of care based on your infertility diagnosis, and create a treatment plan with one or a combination of the following medications.  You can take oral medications, injectable medications, or a combination of oral and injectable medications, which we call a ‘sequential cycle’.


Oral Medications

The main oral medications which are used to stimulate growth of one or more mature eggs are letrozole (Femara) and clomiphene citrate (Clomid).  Your physician may also recommend additional co-treatments to improve your response to the above medications, including metformin (Glucophages), dexamethasone, or tamoxifen.


Injectible medications

Injectable medications include FSH (Follistim, Gonal-F) and hMG (Menopur).  These medications are made of similar hormones that occur naturally in humans, which are released by the brain to signal the ovaries to grow and release an egg each month.  Carolina Conceptions will arrange for you to meet with a nurse to learn just how easy it is to give these injections to yourself, typically on the abdomen just beneath the surface of the skin (much like a diabetic would give themselves an insulin injection).  By administering these medications, we can replicate the pattern of egg growth that should occur in a woman each month, and even get more than one egg to grow for the month.

hCG (Ovidrel, Pregnyl, Novaryl) is another medication which is used as a ‘trigger’, meaning that we trigger the eggs that have grown to release or ovulate.  The hCG injection is used to time intercourse or the insemination appropriately, so that the eggs and sperm come together at just the right time for conception to occur that month.

GnRH agonists (Lupron) and GnRH antagonists (Ganirelix, Cetrotide) are additional injectable medications which can be used to prevent your body from ovulating on its own until your physician determines the time is right and instructs you to take your hCG trigger shot.